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Astrocytic TDP-43 Pathology in Alexander Disease

7 May 2014

Abstract excerpt

Alexander disease (AxD) is a rare neurodegenerative disorder characterized pathologically by the presence of eosinophilic inclusions known as Rosenthal fibers (RFs) within astrocytes, and is caused by dominant mutations in the coding region of the gene encoding glial fibrillary acidic protein (GFAP). GFAP is the major astrocytic intermediate filament, and in AxD patient brain tissue GFAP is a major component of...

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PMID: 24806671
DOI: 10.1523/jneurosci.0248-14.2014

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Astrocytic TDP-43 Pathology in Alexander DiseasePMID 24806671Read ↗

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Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease.Semantic proximity Read ↗

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The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander diseaseSemantic proximity Read ↗

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