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Article

Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers.

British journal of cancer - 1 Feb 2020

Tuna Musaffe, Ju Zhenlin, Yoshihara Kosuke, Amos Christopher I, Tanyi Janos L, Mills Gordon B

Abstract excerpt

BACKGROUND: Mutation of TP53 is the most frequent genetic alteration in high-grade serous ovarian cancer (HGSOC). The impact of hotspot mutations of TP53 and protein levels on patient outcomes in HGSOC has not been fully elucidated. METHODS: The study population (n = 791) comprised of HGSOC samples with TP53 mutation from TCGA and other publicly available data. Univariate and multivariate cox proportional hazards...

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Share to Carcinoma, Ovarian Epithelial
Share to Disease-Free Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gain of Function Mutation

Share to Loss of Function Mutation

Share to Neoplasm Grading

Share to Ovarian Neoplasms

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Source

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Identifiers

PMID: 31780779
DOI: 10.1038/s41416-019-0654-8
PMCID: PMC7000721

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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