Article
Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α.
Genes & development - 1 Feb 2018
Basu Subhasree, Gnanapradeepan Keerthana, Barnoud Thibaut, Kung Che-Pei, Tavecchio Michele, Scott Jeremy, Watters Andrea, Chen Qing, Kossenkov Andrew V, Murphy Maureen E
Abstract excerpt
Mutant forms of p53 protein often possess protumorigenic functions, conferring increased survival and migration to tumor cells via their "gain-of-function" activity. Whether and how a common polymorphism in TP53 at amino acid 72 (Pro72Arg; referred to here as P72 and R72) impacts this gain of function has not been determined. We show that mutant p53 enhances migration and metastasis of tumors through the ability...
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