Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans.

doi:10.1158/1541-7786.MCR-13-0286-T

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans.

Molecular cancer research : MCR - 1 Jul 2014

Weige Charles C, Birtwistle Marc R, Mallick Himel, Yi Nengjun, Berrong Zuzana, Cloessner Emily, Duff Keely, Tidwell Josephine, Clendenning Megan, Wilkerson Brent, Farrell Christopher, Bunz Fred, Ji Hao, Shtutman Michael, Creek Kim E, Banister Carolyn E, Buckhaults Phillip J

Abstract excerpt

UNLABELLED: African Americans are disproportionately affected by early-onset, high-grade malignancies. A fraction of this cancer health disparity can be explained by genetic differences between individuals of African or European descent. Here the wild-type Pro/Pro genotype at the TP53Pro72Arg (P72R) polymorphism (SNP: rs1042522) is more frequent in African Americans with cancer than in African Americans without...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Black or African American

Share to Colonic Neoplasms

Share to Genes, p53

Share to Polymorphism, Single Nucleotide

Share to RNA, Messenger

Share to RNA, Small Interfering

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 24743655
DOI: 10.1158/1541-7786.MCR-13-0286-T
PMCID: PMC4101030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptomes and shRNA suppressors in a TP53 allele-specific model of early-onset colon cancer in African Americans.PMID 24743655Read ↗

Emerging insights into ethnic-specific TP53 germline variants.Semantic proximity Read ↗

PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoidsSemantic proximity Read ↗

The P72R Polymorphism in R248Q/W p53 Mutants Modifies the Mutant Effect on Epithelial to Mesenchymal Transition Phenotype and Cell Invasion via CXCL1 Expression.Semantic proximity Read ↗

Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletion.Semantic proximity Read ↗

Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations.Semantic proximity Read ↗

Adverse Clinical Outcome Associated With Mutations That Typify African American Colorectal Cancers.Semantic proximity Read ↗

Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients.Semantic proximity Read ↗

Identification of new p53 target microRNAs by bioinformatics and functional analysisSemantic proximity Read ↗

Cancer-associated synonymous mutations reveal stress signal-dependent mRNA folding that selectively modulates protein function.Semantic proximity Read ↗

Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity.Semantic proximity Read ↗

Genome-Wide DNA Methylation Analysis Reveals Epigenetic Dysregulation of MicroRNA-34A in TP53 -Associated Cancer SusceptibilitySemantic proximity Read ↗

Suppression of HSF1 activity by wildtype p53 creates the driving force for p53 loss-of-heterozygosity, enabling mutant p53 stabilization and invasionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.