Article
Amplicon deep sequencing of kelch13 in Plasmodium falciparum isolates from Senegal.
Malaria journal - 30 Mar 2020
Gaye Amy, Sy Mouhamad, Ndiaye Tolla, Siddle Katherine J, Park Daniel J, Deme Awa B, Mbaye Aminata, Dieye Baba, Ndiaye Yaye Die, Neafsey Daniel E, Early Angela, Farrell Timothy, Yade Mamadou Samb, Diallo Mamadou Alpha, Diongue Khadim, Bei Amy, Ndiaye Ibrahima Mbaye, Volkman Sarah K, Badiane Aida Sadikh, Ndiaye Daouda
Abstract excerpt
BACKGROUND: In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy (ACT) with artemether-lumefantrine as the first-line treatment for uncomplicated Plasmodium falciparum malaria. To date, multiple mutations associated with artemisinin delayed parasite clearance have been described in Southeast Asia in the Pfk13 gene, such as Y493H, R539T, I543T and C580Y. Even...
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