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Article

Helpless Priming Sends CD8+ T Cells on the Road to Exhaustion

6 Oct 2020

Abstract excerpt

Persistent antigen exposure in chronic infection and cancer has been proposed to lead to cytotoxic T lymphocyte (CTL) “exhaustion”, i.e. loss of effector function and disease control. Recent work identifies a population of poorly differentiated TCF-1+PD-1+ CD8+ T cells as precursors of the terminally exhausted CTL pool. These “predysfunctional” CTLs are suggested to respond to PD-1 targeted therapy by giving rise...

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Identifiers

PMID: 33123174
DOI: 10.3389/fimmu.2020.592569

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