Article
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory.
Nature immunology - 1 Aug 2021
Tonnerre Pierre, Wolski David, Subudhi Sonu, Aljabban Jihad, Hoogeveen Ruben C, Damasio Marcos, Drescher Hannah K, Bartsch Lea M, Tully Damien C, Sen Debattama R, Bean David J, Brown Joelle, Torres-Cornejo Almudena, Robidoux Maxwell, Kvistad Daniel, Alatrakchi Nadia, Cui Ang, Lieb David, Cheney James A, Gustafson Jenna, Lewis-Ximenez Lia L, Massenet-Regad Lucile, Eisenhaure Thomas, Aneja Jasneet, Haining W Nicholas, Chung Raymond T, Hacohen Nir, Allen Todd M, Kim Arthur Y, Lauer Georg M
Abstract excerpt
T cell exhaustion is associated with failure to clear chronic infections and malignant cells. Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to improving immunotherapeutic modalities. Here we confirmed pervasive phenotypic, functional and transcriptional differences between memory and exhausted antigen-specific CD8+ T cells in human hepatitis C virus (HCV) infection before...
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