Article
Precursors of exhausted T cells are pre-emptively formed in acute infection.
Nature - 1 Apr 2025
Chu Talyn, Wu Ming, Hoellbacher Barbara, de Almeida Gustavo P, Wurmser Christine, Berner Jacqueline, Donhauser Lara V, Gerullis Ann-Katrin, Lin Siran, Cepeda-Mayorga J Diego, Kilb Iman I, Bongers Lukas, Toppeta Fabio, Strobl Philipp, Youngblood Ben, Schulz Anna M, Zippelius Alfred, Knolle Percy A, Heinig Matthias, Hackstein Carl-Philipp, Zehn Dietmar
Abstract excerpt
T cell exhaustion limits effector T cell function in chronic infection and tumours1,2. The development of these hypofunctional T cells and of their precursors was considered to require stimulatory conditions that are met only after persistent exposure to antigen and inflammation. Here we show, however, that similar T cell populations exist in the early phase of acute infections1,2. At that stage, the early...
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