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TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation

3 May 2017

Abstract excerpt

Abstract Differentiation and fate of virus-specific CD8 + T cells after cessation of chronic antigen stimulation is unclear. Here we show that a TCF1 + CD127 + PD1 + hepatitis C virus (HCV)-specific CD8 + T-cell subset exists in chronically infected patients with phenotypic features of T-cell exhaustion and memory, both before and after treatment with direct acting antiviral (DAA) agents. This subset is...

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PMID: 28466857
DOI: 10.1038/ncomms15050

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