Article
Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis.
Cell reports - 7 Jun 2016
Pinzaru Alexandra M, Hom Robert A, Beal Angela, Phillips Aaron F, Ni Eric, Cardozo Timothy, Nair Nidhi, Choi Jaehyuk, Wuttke Deborah S, Sfeir Agnel, Denchi Eros Lazzerini
Abstract excerpt
Genome sequencing studies have revealed a number of cancer-associated mutations in the telomere-binding factor POT1. Here, we show that when combined with p53 deficiency, depletion of murine POT1a in common lymphoid progenitor cells fosters genetic instability, accelerates the onset, and increases the severity of T cell lymphomas. In parallel, we examined human and mouse cells carrying POT1 mutations found in...
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