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Article

Molecular profile of Hürthle cell carcinomas: recurrent mutations in the Wnt/β-catenin pathway.

European journal of endocrinology - 1 Dec 2020

Santana Nathalie Oliveira, Lerario Antonio Marcondes, Schmerling Cláudia Kliemann, Marui Suemi, Alves Venancio Avancini Ferreira, Hoff Ana O, Kopp Peter, Danilovic Debora Lucia Seguro

Abstract excerpt

OBJECTIVE: Genomic alterations in Hürthle cell carcinomas (HCC) include chromosomal losses, mitochondrial DNA mutations, and changes in the expression profile of the PI3K-AKT-mTOR and Wnt/β-catenin pathways. This study aimed at characterizing the mutational profile of HCC. METHODS: Next-generation sequencing (NGS) of 40 HCC using a 102-gene panel including, among others, the MAPK, PI3K-AKT-mTOR, Wnt/β-catenin,...

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Identifiers

PMID: 33120354
DOI: 10.1530/EJE-20-0597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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