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Article

Molecular Profile of Advanced Thyroid Carcinomas by Next-Generation Sequencing: Characterizing Tumors Beyond Diagnosis for Targeted Therapy.

Molecular cancer therapeutics - 1 Jul 2018

Chen Hui, Luthra Rajyalakshmi, Routbort Mark J, Patel Keyur P, Cabanillas Maria E, Broaddus Russell R, Williams Michelle D

Abstract excerpt

Next-generation sequencing (NGS) for molecular diagnostics allows simultaneous testing of activating oncogenes and tumor suppressor mutations in multiple signal pathways. Extended mutational profiling of advanced thyroid cancers may enhance considerations for targeted therapies. We analyzed clinically derived molecular profiling of 216 patients with advanced thyroid carcinoma using NGS (Ion Torrent Personal...

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Source

Identifiers

PMID: 29695638
DOI: 10.1158/1535-7163.MCT-17-0871

Genes

BRAF
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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