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Article

Characterization of the mutational landscape of anaplastic thyroid cancer via whole-exome sequencing.

Human molecular genetics - 15 Apr 2015

Kunstman John W, Juhlin C Christofer, Goh Gerald, Brown Taylor C, Stenman Adam, Healy James M, Rubinstein Jill C, Choi Murim, Kiss Nimrod, Nelson-Williams Carol, Mane Shrikant, Rimm David L, Prasad Manju L, Höög Anders, Zedenius Jan, Larsson Catharina, Korah Reju, Lifton Richard P, Carling Tobias

Abstract excerpt

Anaplastic thyroid carcinoma (ATC) is a frequently lethal malignancy that is often unresponsive to available therapeutic strategies. The tumorigenesis of ATC and its relationship to the widely prevalent well-differentiated thyroid carcinomas are unclear. We have analyzed 22 cases of ATC as well as 4 established ATC cell lines using whole-exome sequencing. A total of 2674 somatic mutations (121/sample) were...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

Share to Thyroid Carcinoma, Anaplastic

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Source

Open in PubMed Open full text

Identifiers

PMID: 25576899
DOI: 10.1093/hmg/ddu749
PMCID: PMC4380073

Genes

BRAF
CTNNB1
ERBB2
MLH1
MLH3
MSH5
MSH6
NRAS
RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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