Article
Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes.
Cancer cell - 13 Aug 2018
Ganly Ian, Makarov Vladimir, Deraje Shyamprasad, Dong YiYu, Reznik Ed, Seshan Venkatraman, Nanjangud Gouri, Eng Stephanie, Bose Promita, Kuo Fengshen, Morris Luc G T, Landa Inigo, Carrillo Albornoz Pedro Blecua, Riaz Nadeem, Nikiforov Yuri E, Patel Kepal, Umbricht Christopher, Zeiger Martha, Kebebew Electron, Sherman Eric, Ghossein Ronald, Fagin James A, Chan Timothy A
Abstract excerpt
The molecular foundations of Hürthle cell carcinoma (HCC) are poorly understood. Here we describe a comprehensive genomic characterization of 56 primary HCC tumors that span the spectrum of tumor behavior. We elucidate the mutational profile and driver mutations and show that these tumors exhibit a wide range of recurrent mutations. Notably, we report a high number of disruptive mutations to both protein-coding...
Topics
- Chromosome Aberrations
- DNA Repair
- DNA, Mitochondrial
- Haploidy
- Humans
- Loss of Heterozygosity
- Mutation
- Signal Transduction