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Article

Mutations in the WTX-gene are found in some high-grade microsatellite instable (MSI-H) colorectal cancers.

BMC cancer - 9 Aug 2010

Scheel Silvio K, Porzner Marc, Pfeiffer Sabine, Ormanns Steffen, Kirchner Thomas, Jung Andreas

Abstract excerpt

BACKGROUND: Genetically, colorectal cancers (CRCs) can be subdivided into tumors with chromosomal instability (CIN) or microsatellite instability (MSI). In both types of CRCs genes that are involved in the degradation of beta-CATENIN are frequently mutated. Whereas in CIN CRCs APC (Adenomatous Polyposis Coli) is affected in most cases, high grade MSI (MSI-H) CRCs frequently display mutations in various genes,...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

Open in PubMed Open full text

Identifiers

PMID: 20696052
DOI: 10.1186/1471-2407-10-413
PMCID: PMC2928794

Genes

APC
AXIN2
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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