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Insertion sequence mediating mrgB disruption is the major mechanism of polymyxin resistance in carbapenem-resistant Klebsiella pneumoniae isolates from China

8 Jul 2022

Abstract excerpt

OBJECTIVES: Infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) pose a huge health challenge worldwide. The aim of this study was to evaluate the incidence of polymyxin resistance in clinical CRKP isolates in China and to characterize the molecular mechanisms underlying these polymyxin-resistant CRKP (PR-CRKP) isolates. METHODS: A total of 493 CRKP clinical isolates from patients were collected...

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PMID: 35817263
DOI: 10.1016/j.jgar.2022.07.002

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