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Article

Sperm epigenomics: challenges and opportunities

18 Sept 2014

Abstract excerpt

Sperm is a highly differentiated cell type whose function is to deliver a haploid genome to the oocyte. The sperm "epigenomes" were traditionally considered to be insignificant - the sperm is transcriptionally inactive, its genome is packaged in sperm-specific protamine toroids instead of nucleosomes, and its DNA methylation profile is erased immediately post-fertilization. Yet, in recent years there has been an...

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PMID: 25278962
DOI: 10.3389/fgene.2014.00330

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