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DUBs, the regulation of cell identity and disease

12 Dec 2014

Abstract excerpt

The post-translational modification of proteins with ubiquitin represents a complex signalling system that co-ordinates essential cellular functions, including proteolysis, DNA repair, receptor signalling and cell communication. DUBs (deubiquitinases), the enzymes that disassemble ubiquitin chains and remove ubiquitin from proteins, are central to this system. Reflecting the complexity and versatility of...

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PMID: 25631680
DOI: 10.1042/bj20140496

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