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Role of Deubiquitinases in Human Cancers: Potential Targeted Therapy

6 Apr 2020

Abstract excerpt

Deubiquitinases (DUBs) are involved in various cellular functions. They deconjugate ubiquitin (UBQ) from ubiquitylated substrates to regulate their activity and stability. Studies on the roles of deubiquitylation have been conducted in various cancers to identify the carcinogenic roles of DUBs. In this review, we evaluate the biological roles of DUBs in cancer, including proliferation, cell cycle control,...

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PMID: 32268558
DOI: 10.3390/ijms21072548

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