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Article

Decay of driver mutations shapes the landscape of intestinal transformation.

Nature - 1 Jan 2026

Lourenço Filipe C, Sadien Iannish D, Wong Kim, Adler Sam, Sawle Ashley, Santana Leonor Schubert, Hazelwood Lee, Giavara Giada, Nicholson Anna M, Eldridge Matthew D, Maka Noori, Lynch Gerard, McSorley Stephen T, Edwards Joanne, Kemp Richard, Adams David J, Winton Douglas J

Abstract excerpt

Colorectal cancer (CRC) has traditionally been thought to develop through stepwise mutation of the APC tumour suppressor and other driver genes, coupled with expansion of positively selected clones. However, recent publications show that many premalignant lesions comprise multiple clones expressing different mutant APC proteins1-4. Here, by mediating transformation on different mouse backgrounds containing...

Topics

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Adenomatous Polyposis Coli Protein
beta Catenin
Cell Transformation, Neoplastic
Clone Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Colorectal Neoplasms

Intestinal Mucosa

Proto-Oncogene Proteins p21(ras)

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Open in PubMed Open full text

Identifiers

PMID: 41339549
DOI: 10.1038/s41586-025-09762-w
PMCID: PMC12804087

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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