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Article

Hypermethylation of WNT3A gene and non-syndromic cleft lip and/or palate in association with in utero exposure to lead: A mediation analysis.

Ecotoxicology and environmental safety - 15 Jan 2021

Yang Wenlei, Guo Yingnan, Ni Wenli, Tian Tian, Jin Lei, Liu Jufen, Li Zhiwen, Ren Aiguo, Wang Linlin

Abstract excerpt

OBJECTIVES: We aim to investigate association between WNT3A methylation and risk of non-syndromic cleft lip and/or palate (NSCL/P), and examine mediating effect of WNT3A methylation on the association of NSCL/P and lead (Pb) exposure in fetuses. METHODS: DNA methylation of WNT3A in umbilical cord blood was determined among 59 NSCL/P cases and 118 non-malformed controls. Mediation analysis was performed to...

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PMID: 33091767
DOI: 10.1016/j.ecoenv.2020.111415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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