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Article

PBX-WNT-P63-IRF6 pathway in nonsyndromic cleft lip and palate.

Birth defects research - 1 Feb 2020

Maili Lorena, Letra Ariadne, Silva Renato, Buchanan Edward P, Mulliken John B, Greives Matthew R, Teichgraeber John F, Blackwell Steven J, Ummer Rohit, Weber Ryan, Chiquet Brett, Blanton Susan H, Hecht Jacqueline T

Abstract excerpt

Nonsyndromic cleft lip and palate (NSCLP) is one of the most common craniofacial anomalies in humans, affecting more than 135,000 newborns worldwide. NSCLP has a multifactorial etiology with more than 50 genes postulated to play an etiologic role. The genetic pathway comprised of Pbx-Wnt-p63-Irf6 genes was shown to control facial morphogenesis in mice and proposed as a regulatory pathway for NSCLP. Based on these...

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PMID: 31825181
DOI: 10.1002/bdr2.1630
PMCID: PMC7325739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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