Article
Genome-wide study of gene-by-sex interactions identifies risks for cleft palate.
Human genetics - 1 Nov 2024
Robinson Kelsey, Parrish Randy, Adeyemo Wasiu Lanre, Beaty Terri H, Butali Azeez, Buxó Carmen J, Gowans Lord J J, Hecht Jacqueline T, Moreno Uribe Lina, Murray Jeffrey C, Shaw Gary M, Weinberg Seth M, Brand Harrison, Marazita Mary L, Cutler David J, Epstein Michael P, Yang Jingjing, Leslie Elizabeth J
Abstract excerpt
Structural birth defects affect 3-4% of all live births and, depending on the type, tend to manifest in a sex-biased manner. Orofacial clefts (OFCs) are the most common craniofacial structural birth defects and are often divided into cleft lip with or without cleft palate (CL/P) and cleft palate only (CP). Previous studies have found sex-specific risks for CL/P, but these risks have yet to be evaluated in CP....
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