Article
Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases.
Journal of the American Medical Informatics Association : JAMIA - 1 Jan 2000
Lee Younghee, Li Haiquan, Li Jianrong, Rebman Ellen, Achour Ikbel, Regan Kelly E, Gamazon Eric R, Chen James L, Yang Xinan Holly, Cox Nancy J, Lussier Yves A
Abstract excerpt
BACKGROUND: While genome-wide association studies (GWAS) of complex traits have revealed thousands of reproducible genetic associations to date, these loci collectively confer very little of the heritability of their respective diseases and, in general, have contributed little to our understanding the underlying disease biology. Physical protein interactions have been utilized to increase our understanding of...
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