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Article

Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.

Nature medicine - 1 Oct 2003

Mialet Perez Jeanne, Rathz Deborah A, Petrashevskaya Natalia N, Hahn Harvey S, Wagoner Lynne E, Schwartz Arnold, Dorn Gerald W, Liggett Stephen B

Abstract excerpt

Catecholamines stimulate cardiac contractility through beta(1)-adrenergic receptors (beta(1)-ARs), which in humans are polymorphic at amino acid residue 389 (Arg/Gly). We used cardiac-targeted transgenesis in a mouse model to delineate mechanisms accounting for the association of Arg389 with human heart failure phenotypes. Hearts from young Arg389 mice had enhanced receptor function and contractility compared...

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Source

Identifiers

PMID: 14502278
DOI: 10.1038/nm930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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