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Article

KCNJ2 mutation causes an adrenergic-dependent rectification abnormality with calcium sensitivity and ventricular arrhythmia.

Heart rhythm - 1 May 2014

Kalscheur Matthew M, Vaidyanathan Ravi, Orland Kate M, Abozeid Sara, Fabry Nicholas, Maginot Kathleen R, January Craig T, Makielski Jonathan C, Eckhardt Lee L

Abstract excerpt

BACKGROUND: KCNJ2 mutations are associated with a variety of inherited arrhythmia syndromes including catecholaminergic polymorphic ventricular tachycardia 3. OBJECTIVE: To characterize the detailed cellular mechanisms of the clinically recognized KCNJ2 mutation R67Q. METHODS: Kir2.1 current density was measured from COS-1 cells transiently transfected with wild-type human Kir-2.1 (WT-Kir2.1) and/or a...

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Source

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Identifiers

PMID: 24561538
DOI: 10.1016/j.hrthm.2014.02.015
PMCID: PMC4257478

Genes

KCNJ2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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