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Article

Factor H‐related protein 1: a complement regulatory protein and guardian of necrotic‐type surfaces

21 Oct 2020

Abstract excerpt

Factor H-related protein 1 (FHR-1) is a member of the factor H protein family, which is involved in regulating innate immune complement reactions. Genetic modification of the encoding gene, CFHR1 on human chromosome 1, is involved in diseases such as age-related macular degeneration, C3 glomerulopathy and atypical haemolytic uraemic syndrome, indicating an important role for FHR-1 in human health. Recent research...

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PMID: 33085794
DOI: 10.1111/bph.15290

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