Article
Immobilization of arrestin-3 on different biosensor platforms for evaluating GPCR binding.
Physical chemistry chemical physics : PCCP - 28 Oct 2020
Avsar Saziye Yorulmaz, Kapinos Larisa E, Schoenenberger Cora-Ann, Schertler Gebhard F X, Mühle Jonas, Meger Benoit, Lim Roderick Y H, Ostermaier Martin K, Lesca Elena, Palivan Cornelia G
Abstract excerpt
G protein-coupled receptors (GPCRs) are a large and ubiquitous family of membrane receptors of great pharmacological interest. Cell-based assays are the primary tool for assessing GPCR interactions and activation but their design and intrinsic complexity limit their application. Biosensor-based assays that directly and specifically report GPCR-protein binding (e.g. arrestin or G protein) could provide a good...
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