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Article

Molecular dissection of the human A3 adenosine receptor coupling with β-arrestin2.

Biochemical pharmacology - 1 Feb 2018

Storme Jolien, Cannaert Annelies, Van Craenenbroeck Kathleen, Stove Christophe P

Abstract excerpt

Besides classical G protein coupling, G protein-coupled receptors (GPCRs) are nowadays well known to show significant signalling via other adaptor proteins, such as β-arrestin2 (βarr2). The elucidation of the molecular mechanism of the GPCR-βarr2 interaction is a prerequisite for the structure-activity based design of biased ligands, which introduces a new chapter in drug discovery. The general mechanism of the...

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PMID: 29309765
DOI: 10.1016/j.bcp.2018.01.008

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