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Article

Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant.

The Journal of biological chemistry - 1 Jun 2012

Breitman Maya, Kook Seunghyi, Gimenez Luis E, Lizama Britney N, Palazzo Maria C, Gurevich Eugenia V, Gurevich Vsevolod V

Abstract excerpt

We established a new in vivo arrestin-3-JNK3 interaction assay based on bioluminescence resonance energy transfer (BRET) between JNK3-luciferase and Venus-arrestins. We tested the ability of WT arrestin-3 and its 3A mutant that readily binds β2-adrenergic receptors as well as two mutants impaired in receptor binding, Δ7 and KNC, to directly bind JNK3 and to promote JNK3 phosphorylation in cells. Both receptor...

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Identifiers

PMID: 22523077
DOI: 10.1074/jbc.M112.358192
PMCID: PMC3366000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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