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Article

Analysis of temporal patterns of GPCR-β-arrestin interactions using split luciferase-fragment complementation.

Molecular bioSystems - 1 May 2013

Hattori Mitsuru, Tanaka Miho, Takakura Hideo, Aoki Kiyono, Miura Kenji, Anzai Tomohiro, Ozawa Takeaki

Abstract excerpt

We developed bioluminescence probes to detect quantitative interaction of GPCRs with arrestin isoforms β-arrestin1 and β-arrestin2 based on split luciferase complementation. Time-dependent GPCR-β-arrestin interactions showed two-types of remarkable variations that were consistent with a classification of GPCR classes. Positive charge residues in serine clusters located at the C-terminal region of GPCRs were...

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Identifiers

PMID: 23302795
DOI: 10.1039/c2mb25443c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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