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Article

Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis.

PloS one - 1 Jan 2019

Berger Toni C, Vigeland Magnus D, Hjorthaug Hanne S, Etholm Lars, Nome Cecilie G, Taubøll Erik, Heuser Kjell, Selmer Kaja K

Abstract excerpt

BACKGROUND AND AIMS: Mesial Temporal Lobe Epilepsy is characterized by progressive changes of both neurons and glia, also referred to as epileptogenesis. No curative treatment options, apart from surgery, are available. DNA methylation (DNAm) is a potential upstream mechanism in epileptogenesis and may serve as a novel therapeutic target. To our knowledge, this is the first study to investigate epilepsy-related...

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Identifiers

PMID: 31887157
DOI: 10.1371/journal.pone.0226575
PMCID: PMC6936816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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