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Article

UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

1 Sept 2019

Abstract excerpt

Although clonal neo-antigen burden is associated with improved response to immune therapy, the functional basis for this remains unclear. Here we study this question in a novel controlled mouse melanoma model that enables us to explore the effects of intra-tumor heterogeneity (ITH) on tumor aggressiveness and immunity independent of tumor mutational burden. Induction of UVB-derived mutations yields highly...

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PMID: 31522890
DOI: 10.1016/j.cell.2019.08.032

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