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Article

Associations of NOD2 polymorphisms with Erysipelotrichaceae in stool of in healthy first degree relatives of Crohn's disease subjects.

BMC medical genetics - 15 Oct 2020

Turpin Williams, Bedrani Larbi, Espin-Garcia Osvaldo, Xu Wei, Silverberg Mark S, Smith Michelle I, Garay Juan Antonio Raygoza, Lee Sun-Ho, Guttman David S, Griffiths Anne, Moayyedi Paul, Panaccione Remo, Huynh Hien, Steinhart Hillary A, Aumais Guy, Dieleman Levinus A, Turner Dan, Paterson Andrew D, Croitoru Kenneth

Abstract excerpt

BACKGROUND: Genetic analyses have identified many variants associated with the risk of inflammatory bowel disease (IBD) development. Among these variants, the ones located within the NOD2 gene have the highest odds ratio of all IBD genetic risk variants. Also, patients with Crohn's disease (CD) have been shown to have an altered gut microbiome, which might be a reflection of inflammation itself or an effect of...

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PMID: 33059653
DOI: 10.1186/s12881-020-01115-w
PMCID: PMC7566148

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