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Article

The Impact of NOD2 Variants on Fecal Microbiota in Crohn's Disease and Controls Without Gastrointestinal Disease.

Inflammatory bowel diseases - 15 Feb 2018

Kennedy Nicholas A, Lamb Christopher A, Berry Susan H, Walker Alan W, Mansfield John, Parkes Miles, Simpkins Rachel, Tremelling Mark, Nutland Sarah, Parkhill Julian, Probert Chris, Hold Georgina L, Lees Charlie W

Abstract excerpt

Background/Aims: Current models of Crohn's disease (CD) describe an inappropriate immune response to gut microbiota in genetically susceptible individuals. NOD2 variants are strongly associated with development of CD, and NOD2 is part of the innate immune response to bacteria. This study aimed to identify differences in fecal microbiota in CD patients and non-IBD controls stratified by NOD2 genotype. Methods:...

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Source

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Identifiers

PMID: 29462388
DOI: 10.1093/ibd/izx061
PMCID: PMC6176884

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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