Article
The Impact of NOD2 Genetic Variants on the Gut Mycobiota in Crohn's Disease Patients in Remission and in Individuals Without Gastrointestinal Inflammation.
Journal of Crohn's & colitis - 4 May 2021
Nelson Andrew, Stewart Christopher J, Kennedy Nicholas A, Lodge John K, Tremelling Mark, Probert Chris S, Parkes Miles, Mansfield John C, Smith Darren L, Hold Georgina L, Lees Charlie W, Bridge Simon H, Lamb Christopher A
Abstract excerpt
BACKGROUND AND AIMS: Historical and emerging data implicate fungi in Crohn's disease [CD] pathogenesis. However, a causal link between mycobiota, dysregulated immunity, and any impact of NOD2 variants remains elusive. This study aims to evaluate associations between NOD2 variants and faecal mycobiota in CD patients and non-CD subjects. METHODS: Faecal samples were obtained from 34 CD patients [18 NOD2 mutant, 16...
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