Article
Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease.
Gastroenterology - 1 Sept 2002
Abreu Maria T, Taylor Kent D, Lin Ying-Chao, Hang Tieu, Gaiennie Joanne, Landers Carol J, Vasiliauskas Eric A, Kam Lori Y, Rojany Micha, Papadakis Konstantinos A, Rotter Jerome I, Targan Stephan R, Yang Huiying
Abstract excerpt
BACKGROUND & AIMS: The clinical manifestations of Crohn's disease (CD) are diverse, ranging from fibrostenosing small-bowel disease to colon-predominant inflammation. These distinctions may represent genetic, immunologic, and microbial heterogeneity. NOD2 gene mutations in CD have been described recently and may alter innate immune responses. We hypothesized that NOD2 mutations may be associated with distinct...
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