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Article

Detection of glioblastoma intratumor heterogeneity in radiosensitivity using patient-derived neurosphere cultures.

Journal of neuro-oncology - 1 Sept 2020

McAbee Joseph H, Degorre-Kerbaul Charlotte, Valdez Kristin, Wendler Astrid, Shankavaram Uma T, Watts Colin, Camphausen Kevin, Tofilon Philip J

Abstract excerpt

PURPOSE: Glioblastoma (GBM) is characterized by extensive clonal diversity suggesting the presence of tumor cells with varying degrees of treatment sensitivity. Radiotherapy is an integral part of glioblastoma treatment. Whether GBMs are comprised of spatially distinct cellular populations with uniform or varying degrees of radiosensitivity has not been established. METHODS: Spatially distinct regions of three...

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Source

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Identifiers

PMID: 33057920
DOI: 10.1007/s11060-020-03643-0
PMCID: PMC8942292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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