Article
Integrated clinico-molecular profiling of appendiceal adenocarcinoma reveals a unique grade-driven entity distinct from colorectal cancer.
British journal of cancer - 1 Oct 2020
Raghav Kanwal, Shen John P, Jácome Alexandre A, Guerra Jennifer L, Scally Christopher P, Taggart Melissa W, Foo Wai C, Matamoros Aurelio, Shaw Kenna R, Fournier Keith, Overman Michael J, Eng Cathy
Abstract excerpt
BACKGROUND: Appendiceal adenocarcinoma (AA) is an orphan disease with unique clinical attributes but often treated as colorectal cancer (CRC). Understanding key molecular differences between AA and CRC is critical. METHODS: We performed retrospective analyses of AA patients (N = 266) with tumour and/or blood next-generation sequencing (NGS) (2013-2018) with in-depth clinicopathological annotation. Overall...
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