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Distinct Genomic Landscape of Colorectal Signet Ring Cell Carcinoma Reveals Frequent KMT2 Family Alterations and SMAD4 Inactivation

2026-04-19

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<title>Abstract</title> <p> Background Signet ring cell colorectal carcinoma (SRCC) is a rare and highly aggressive subtype of colorectal cancer associated with poor clinical outcomes. Despite its distinct pathology, SRCC remains underrepresented in large genomic datasets, and its molecular drivers are incompletely defined. We performed comprehensive genomic profiling to characterize the mutational landscape of...

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Literature Corpus work
438d341d-c8fc-5e3c-ab73-49b749203112
DOI
10.21203/rs.3.rs-9128596/v1
Open publication

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Distinct Genomic Landscape of Colorectal Signet Ring Cell Carcinoma Reveals Frequent KMT2 Family Alterations and SMAD4 InactivationDOI 10.21203/rs.3.rs-9128596/v1
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