Article
Genomic profiling of intestinal-type sinonasal adenocarcinoma reveals subgroups of patients with distinct clinical outcomes.
Head & neck - 1 Feb 2018
López-Hernández Alejandro, Pérez-Escuredo Jhudit, Vivanco Blanca, García-Inclán Cristina, Potes-Ares Sira, Cabal Virginia N, Riobello Cristina, Costales María, López Fernando, Llorente José Luis, Hermsen Mario A
Abstract excerpt
BACKGROUND: Patients with intestinal-type sinonasal adenocarcinoma (ITAC) have an unfavorable prognosis and new therapeutic approaches are needed to improve clinical management. METHODS: Genetic analysis of 96 ITACs was performed by microarray comparative genomic hybridization and immunohistochemistry and correlated to previously obtained mutation, methylation, and protein expression data, and with pathological...
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