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Article

HLA-A alleles influencing NK cell function impact AML relapse following allogeneic hematopoietic cell transplantation.

Blood advances - 13 Oct 2020

van der Ploeg Kattria, Le Luduec Jean-Benoît, Stevenson Philip A, Park Soo, Gooley Ted A, Petersdorf Effie W, Shaffer Brian C, Hsu Katharine C

Abstract excerpt

HLA-B allotypes exhibiting the Bw4 epitope trigger variable inhibitory signaling of KIR3DL1 receptor types, where strong inhibitory HLA-B and KIR3DL1 allele combinations are associated with increased risk for relapse of acute myelogenous leukemia (AML) following allogeneic hematopoietic cell transplantation (HCT). Several HLA-A allotypes also exhibit the Bw4 epitope. Studies with natural killer (NK) cell clones...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33049053
DOI: 10.1182/bloodadvances.2020002086
PMCID: PMC7556125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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