Article

HLA-B*44 and the Bw4-80T motif are associated with poor outcome of relapse-preventive immunotherapy in acute myeloid leukemia

2023-05-01

Abstract excerpt

HLA-B proteins interact with key immune receptors on both T and NK cells, and variants of the encoding gene are associated with outcomes in various pathologies, including autoimmune diseases and malignancies. HLA-B is pivotal in antigen presentation to cytotoxic T cells, and some variants containing a Bw4 motif also serve as ligands to the killer immunoglobulin-like receptors (KIR) 3DL1/S1 of NK cells. We investig...

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Literature Corpus work: afbec5fc-3ac9-5b27-90ec-cd3e3c7a10f5
DOI: 10.21203/rs.3.rs-2860436/v1

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