IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection

Abstract excerpt

Inflammation is critical for controlling pathogens, but also responsible for symptoms of infectious diseases.IL-27 is an important regulator of inflammation and can limit development of IFNγ-producing Tbet + CD4 + T (Th1) cells.IL-27 is thought to do this by stimulating IL-10 production by CD4 + T cells, but the underlying mechanisms of these immunoregulatory pathways are not clear.Here we studied the role of...

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