Article

IL-35 produced by dendritic cells via TIM-3-STAT3 signaling contributes to the development of visceral leishmaniasis

2026-02-24

Abstract excerpt

<h4>ABSTRACT</h4> Visceral leishmaniasis (VL), a life-threatening parasitic disease caused by Leishmania donovani (LD), progresses primarily due to profound immunosuppression. However, the molecular and cellular mechanisms underlying this immune dysfunction remain poorly defined. Here we show that early production of IL-35 by dendritic cells (DCs) is critical for immunosuppression and disease pathogenesis during...

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Literature Corpus work: 515bd201-eb00-5c12-8abe-217beb1a7eb7
DOI: 10.64898/2026.02.23.707416

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