Article

<i>Leishmania mexicana Centrin</i> Knock out Parasites Promote M1-polarizing Metabolic Changes

2022-09-16

Abstract excerpt

<h4>ABSTRACT</h4> Leishmaniasis is a tropical disease present in more than 90 countries. Presently, there is no approved vaccine for human use. We have previously developed live attenuated L. mexicana Cen −/− (LmexCen −/− ) as a vaccine candidate that showed excellent efficacy that was characterized by reduced activation of Th2 responses and enhanced Th1 responses, contrary to wild type L. mexicana (Lmex WT...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f25bc8df-9ef2-5488-b2f8-236885aa88ca
DOI: 10.1101/2022.09.16.508215

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Leishmania mexicana Centrin</i> Knock out Parasites Promote M1-polarizing Metabolic ChangesDOI 10.1101/2022.09.16.508215Read

<i>Leishmania major centrin</i> knock-out parasites alter the kynurenine- aryl hydrocarbon receptor signaling to produce a pro-inflammatory responseSemantic proximity Read

Centrin-deficient <i>Leishmania mexicana</i> confers protection against Old World visceral leishmaniasisSemantic proximity Read

Tissue specific dual RNA-seq defines host-parasite interplay in murine visceral leishmaniasis caused by <i>Leishmania donovani</i> and <i>Leishmania infantum</i>Semantic proximity Read

Exploring <i>Leishmania</i> -Host Interaction with Reactome, a Database of Biological Pathways and ProcessesSemantic proximity Read

The metabolic program of inflammatory eosinophils accounts for chronic parasite-induced skin diseaseSemantic proximity Read

Macrophage Polarization in Leishmaniasis: Broadening HorizonsSemantic proximity Read

Simultaneous transcriptional profiling of Leishmania major and its murine macrophage host cell reveals insights into host-pathogen interactionsSemantic proximity Read

Skin resident memory cells generated by the <i>L. major</i> centrin gene deleted parasites mediate protective immune response analogous to leishmanizationSemantic proximity Read

<i>Leishmania</i> targets the macrophage epigenome and dampens the NF-κB/NLRP3-mediated inflammatory responseSemantic proximity Read

Drug-induced metabolic remodeling of immune cell repertoire generates an effective broad-range antimicrobial effectSemantic proximity Read

<i>Leishmania</i> and the Macrophage: A Multifaceted InteractionSemantic proximity Read

Neglected Tropical Diseases and Omics Science: Proteogenomics Analysis of the Promastigote Stage of <i>Leishmania major</i> ParasiteSemantic proximity Read