Article

β-catenin driven innate and metabolic reprograming in macrophages fuel T-cells dependent inflammation in Toxoplasma gondii infection: implications for therapeutic intervention

2026-02-09

Abstract excerpt

<title>Abstract</title> Toxoplasma gondii activates innate immunity via TLR11/12 in mice, but the lack of functional human counterparts leaves a gap in understanding parasite sensing in humans. Here, we bridge this gap by uncovering a host-intrinsic sensing mechanism, wherein β-catenin signaling mediates immune recognition of T. gondii. Notably, this parasite hijacks the PI3K-AKT-β-catenin pathway in macrophag...

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Literature Corpus work: 94bb3236-f290-5d7f-bd3e-6d29e751df42
DOI: 10.21203/rs.3.rs-8453530/v1

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β-catenin driven innate and metabolic reprograming in macrophages fuel T-cells dependent inflammation in Toxoplasma gondii infection: implications for therapeutic interventionDOI 10.21203/rs.3.rs-8453530/v1Read

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