Article
A Bayesian Mutation-Selection Framework for Detecting Site-Specific Adaptive Evolution in Protein-Coding Genes.
Molecular biology and evolution - 9 Mar 2021
Rodrigue Nicolas, Latrille Thibault, Lartillot Nicolas
Abstract excerpt
In recent years, codon substitution models based on the mutation-selection principle have been extended for the purpose of detecting signatures of adaptive evolution in protein-coding genes. However, the approaches used to date have either focused on detecting global signals of adaptive regimes-across the entire gene-or on contexts where experimentally derived, site-specific amino acid fitness profiles are...
Topics
- Bayes Theorem
- Biological Evolution
- Genetic Techniques
- Models, Genetic
- Mutation
- Selection, Genetic