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Article

Inferring the number and position of changes in selective regime in a non-equilibrium mutation-selection framework.

BMC ecology and evolution - 10 Mar 2021

Ritchie Andrew M, Stark Tristan L, Liberles David A

Abstract excerpt

BACKGROUND: Recovering the historical patterns of selection acting on a protein coding sequence is a major goal of evolutionary biology. Mutation-selection models address this problem by explicitly modelling fixation rates as a function of site-specific amino acid fitness values.However, they are restricted in their utility for investigating directional evolution because they require prior knowledge of the...

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Identifiers

PMID: 33691618
DOI: 10.1186/s12862-021-01770-4
PMCID: PMC7944921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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