Mutation bias shapes the spectrum of adaptive substitutions.

Abstract excerpt

Evolutionary adaptation often occurs by the fixation of beneficial mutations. This mode of adaptation can be characterized quantitatively by a spectrum of adaptive substitutions, i.e., a distribution for types of changes fixed in adaptation. Recent work establishes that the changes involved in adaptation reflect common types of mutations, raising the question of how strongly the mutation spectrum shapes the...

Topics

• Adaptation, Physiological
• Bacterial Proteins
• Escherichia coli
• Fungal Proteins
• Gene Expression Regulation, Bacterial
• Gene Expression Regulation, Fungal
• Mutation
• Mycobacterium tuberculosis
• Saccharomyces cerevisiae
• Species Specificity